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Technical Brief

November 4th, 2022
Emerging SARS-CoV-2 Variants
and Detection by the Lucira COVID-19 Check-It and All-In-One Test Kits

The Centers for Disease Control and Prevention (CDC) and the World Health Organization
(WHO) have highlighted surveillance of the following Omicron lineages:


(1) BA.2.3.20, BA.2.75, BA.2.75.2, BA.4, BA.4.6, BA.5, BA.5.2.6, BF.7, BJ.1, BQ.1, BQ.1.1, XBB
Additionally, six other variants have been under continued surveillance despite their lower
prevalence:


(2) Delta (also known as B.1.617.2, all sublineages) first detected in India,


(3) Alpha (also known as B.1.1.7, all sublineages) first detected in the United Kingdom,


(4) Beta (also known as B.1.351, all sublineages) first detected in South Africa,


(5) Gamma (also known as P.1, all sublineages) first detected in Japan/Brazil,


(6) Lambda (also known as C.37, all sublineages) first detected in Peru,


(7) Mu (also known as B.1.621, all sublineages) first detected in Colombia


Lucira Health performs routine surveillance of emerging SARS-CoV-2 strains by periodically
evaluating in silico reactivity against sequence databases. These evaluations have shown that
these variants are reactive to the Lucira COVID-19 Check-It and All-In-One Test Kits. The Lucira
Health assay targets two non-overlapping regions of the SARS-CoV-2 genome. The detection
regions are unaffected by the mutations in the spike protein of SARS-CoV-2 in the variant strains.


Lucira Health will continue to monitor the situation with emerging variants of SARS-CoV-2.

If you have any questions on the above, please reach out to Technical Support at
techsupport@lucirahealth.com.

1https://www.cdc.gov/coronavirus/2019-ncov/variants/variant-info.html

2https://www.who.int/en/activities/tracking-SARS-CoV-2-variants/